Biology of Blood and Marrow Transplantation
Volume 16, Issue 8 , Pages 1099-1106 , August 2010

Second Unrelated Donor Hematopoietic Cell Transplantation for Primary Graft Failure

  • Jeffrey Schriber

      Affiliations

    • Banner Blood Marrow Transplant Program and City of Hope Banner, Phoenix, Arizona
    • ,
  • Manza-A. Agovi

      Affiliations

    • Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Vincent Ho

      Affiliations

    • Dana-Farber Cancer Institute, Boston, Massachusetss
    • ,
  • Karen K. Ballen

      Affiliations

    • Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Andrea Bacigalupo

      Affiliations

    • Ospedale San Martino, Genova, Italy
    • ,
  • Hillard M. Lazarus

      Affiliations

    • University Hospitals Case Medical Center, Cleveland, Ohio
    • ,
  • Christopher N. Bredeson

      Affiliations

    • Froedert Memorial Lutheran Hospital, Milwaukee, Wisconsin
    • ,
  • Vikas Gupta

      Affiliations

    • Princess Margaret Hospital, Toronto, Canada
    • ,
  • Richard T. Maziarz

      Affiliations

    • Oregon Health and Science University, Portland, Orgeon
    • ,
  • Gregory A. Hale

      Affiliations

    • All Children's Hospital, St. Petersburg, Florida
    • ,
  • Mark R. Litzow

      Affiliations

    • Mayo Clinic, Rochester, Minnesota
    • ,
  • Brent Logan

      Affiliations

    • Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Martin Bornhauser

      Affiliations

    • Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    • ,
  • Roger H. Giller

      Affiliations

    • University of Colorado Children's Hospital, Aurora, Colorado
    • ,
  • Luis Isola

      Affiliations

    • Mount Sinai Hospital, New York, New York
    • ,
  • David I. Marks

      Affiliations

    • Bristol Children's Hospital, Bristol, United Kingdom
    • ,
  • J. Douglas Rizzo

      Affiliations

    • Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Marcelo C. Pasquini

      Affiliations

    • Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin
    • Corresponding Author InformationCorrespondence and reprint requests: Marcelo C. Pasquini, MD, MS, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, 9200 W. Wisconsin Ave., Suite CC5500, Milwaukee, WI 53226.

Received 30 December 2009 ,Accepted 15 February 2010.

References 

  1. Champlin RE, Horowitz MM, van Bekkum DW, et al. Graft failure following bone marrow transplantation for severe aplastic anemia: risk factors and treatment results. Blood. 1989;73:606–613
  2. McCann SR, Bacigalupo A, Gluckman E, et al. Graft rejection and second bone marrow transplants for acquired aplastic anaemia: a report from the Aplastic Anaemia Working Party of the European Bone Marrow Transplant Group. Bone Marrow Transplant. 1994;13:233–237
  3. Storb R, Longton G, Anasetti C, et al. Changing trends in marrow transplantation for aplastic anemia. Bone Marrow Transplant. 1992;10(Suppl 1):45–52
  4. Arfons LM, Tomblyn M, Rocha V, Lazarus HM. Second hematopoietic stem cell transplantation in myeloid malignancies. Curr Opin Hematol. 2009;16:112–123
  5. Byrne BJ, Horwitz M, Long GD, et al. Outcomes of a second non-myeloablative allogeneic stem cell transplantation following graft rejection. Bone Marrow Transplant. 2008;41:39–43
  6. Chewning JH, Castro-Malaspina H, Jakubowski A, et al. Fludarabine-based conditioning secures engraftment of second hematopoietic stem cell allografts (HSCT) in the treatment of initial graft failure. Biol Blood Marrow Transplant. 2007;13:1313–1323
  7. Grandage VL, Cornish JM, Pamphilon DH, et al. Second allogeneic bone marrow transplants from unrelated donors for graft failure following initial unrelated donor bone marrow transplantation. Bone Marrow Transplant. 1998;21:687–690
  8. Guardiola P, Kuentz M, Garban F, et al. Second early allogeneic stem cell transplantations for graft failure in acute leukaemia, chronic myeloid leukaemia and aplastic anaemia. French Society of Bone Marrow Transplantation. Br J Haematol. 2000;111:292–302
  9. Jabbour E, Rondon G, Anderlini P, et al. Treatment of donor graft failure with nonmyeloablative conditioning of fludarabine, antithymocyte globulin and a second allogeneic hematopoietic transplantation. Bone Marrow Transplant. 2007;40:431–435
  10. Nemunaitis J, Singer JW, Buckner CD, et al. Use of recombinant human granulocyte-macrophage colony-stimulating factor in graft failure after bone marrow transplantation. Blood. 1990;76:245–253
  11. Platzbecker U, Binder M, Schmid C, Rutt C, Ehninger G, Bornhauser M. Second donation of hematopoietic stem cells from unrelated donors for patients with relapse or graft failure after allogeneic transplantation. Haematologica. 2008;93:1276–1278
  12. Remberger M, Ringden O, Ljungman P, et al. Booster marrow or blood cells for graft failure after allogeneic bone marrow transplantation. Bone Marrow Transplant. 1998;22:73–78
  13. Rondon G, Saliba RM, Khouri I, et al. Long-term follow-up of patients who experienced graft failure postallogeneic progenitor cell transplantation. Results of a single institution analysis. Biol Blood Marrow Transplant. 2008;14:859–866
  14. Shimada K, Narimatsu H, Morishita Y, Kohno A, Saito S, Kato Y. Severe regimen-related toxicity of second transplantation for graft failure following reduced-intensity cord blood transplantation in an adult patient. Bone Marrow Transplant. 2006;37:787–788
  15. Stelljes M, van Biezen A, Slavin S, et al. The harvest and use of autologous back-up grafts for graft failure or severe GVHD after allogeneic hematopoietic stem cell transplantation: a survey of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant. 2008;42:739–742
  16. Weisdorf DJ, Verfaillie CM, Davies SM, et al. Hematopoietic growth factors for graft failure after bone marrow transplantation: a randomized trial of granulocyte-macrophage colony-stimulating factor (GM-CSF) versus sequential GM-CSF plus granulocyte-CSF. Blood. 1995;85:3452–3456
  17. Mehta J, Powles R, Singhal S, et al. Early identification of patients at risk of death due to infections, hemorrhage, or graft failure after allogeneic bone marrow transplantation on the basis of the leukocyte counts. Bone Marrow Transplant. 1997;19:349–355
  18. Pottinger B, Walker M, Campbell M, Holyoake TL, Franklin IM, Cook G. The storage and re-infusion of autologous blood and BM as back-up following failed primary hematopoietic stem-cell transplantation: a survey of European practice. Cytotherapy. 2002;4:127–135
  19. Fernandes J, Rocha V, Robin M, et al. Second transplant with two unrelated cord blood units for early graft failure after haematopoietic stem cell transplantation. Br J Haematol. 2007;137:248–251

 Financial disclosure: See Acknowledgments on page 1105.

PII: S1083-8791(10)00084-4

doi: 10.1016/j.bbmt.2010.02.013

Biology of Blood and Marrow Transplantation
Volume 16, Issue 8 , Pages 1099-1106 , August 2010

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