Biology of Blood and Marrow Transplantation
Volume 16, Issue 8 , Pages 1130-1137 , August 2010

Accelerated Bone Mineral Density Loss Occurs with Similar Incidence and Severity, But with Different Risk Factors, after Autologous versus Allogeneic Hematopoietic Cell Transplantation

  • Song Yao

      Affiliations

    • Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York
    • ,
  • Shannon L. Smiley

      Affiliations

    • Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York
    • ,
  • Kathleen West

      Affiliations

    • Department of Pharmacy, Roswell Park Cancer Institute, Buffalo, New York
    • ,
  • Dominick Lamonica

      Affiliations

    • Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, New York
    • ,
  • Minoo Battiwalla

      Affiliations

    • Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York
    • ,
  • Philip L. McCarthy Jr.

      Affiliations

    • Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York
    • ,
  • Theresa Hahn

      Affiliations

    • Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York
    • Corresponding Author InformationCorrespondence and reprint requests: Theresa Hahn, PhD, Department of Medicine, BMT Program, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263.

Received 13 January 2010 ,Accepted 19 February 2010.

References 

  1. Copelan EA. Hematopoietic stem-cell transplantation. N Engl J Med. 2006;354:1813–1826
  2. Henderson NK, Sambrook PN, Kelly PJ, et al. Bone mineral loss and recovery after cardiac transplantation. Lancet. 1995;346:905
  3. Horber FF, Casez JP, Steiger U, Czerniak A, Montandon A, Jaeger P. Changes in bone mass early after kidney transplantation. J Bone Miner Res. 1994;9:1–9
  4. Spira A, Gutierrez C, Chaparro C, Hutcheon MA, Chan CK. Osteoporosis and lung transplantation: a prospective study. Chest. 2000;117:476–481
  5. Schulte C, Beelen DW, Schaefer UW, Mann K. Bone loss in long-term survivors after transplantation of hematopoietic stem cells: a prospective study. Osteoporos Int. 2000;11:344–353
  6. Schulte CM, Beelen DW. Bone loss following hematopoietic stem cell transplantation: a long-term follow-up. Blood. 2004;103:3635–3643
  7. Stern JM, Sullivan KM, Ott SM, et al. Bone density loss after allogeneic hematopoietic stem cell transplantation: a prospective study. Biol Blood Marrow Transplant. 2001;7:257–264
  8. Ebeling PR. Approach to the patient with transplantation-related bone loss. J Clin Endocrinol Metab. 2009;94:1483–1490
  9. Faulkner KG. Bone matters: are density increases necessary to reduce fracture risk?. J Bone Miner Res. 2000;15:183–187
  10. Khosla S, Melton LJ. Clinical practice. Osteopenia. N Engl J Med. 2007;356:2293–2300
  11. Yao S, McCarthy PL, Dunford LM, et al. High prevalence of early-onset osteopenia/osteoporosis after allogeneic stem cell transplantation and improvement after bisphosphonate therapy. Bone Marrow Transplant. 2008;41:393–398
  12. Tauchmanova L, De Simone G, Musella T, et al. Effects of various antireabsorptive treatments on bone mineral density in hypogonadal young women after allogeneic stem cell transplantation. Bone Marrow Transplant. 2006;37:81–88
  13. Tauchmanova L, Ricci P, Serio B, et al. Short-term zoledronic acid treatment increases bone mineral density and marrow clonogenic fibroblast progenitors after allogeneic stem cell transplantation. J Clin Endocrinol Metab. 2005;90:627–634
  14. Kananen K, Volin L, Laitinen K, Alfthan H, Ruutu T, Valimaki MJ. Prevention of bone loss after allogeneic stem cell transplantation by calcium, vitamin D, and sex hormone replacement with or without pamidronate. J Clin Endocrinol Metab. 2005;90:3877–3885
  15. D'Souza AB, Grigg AP, Szer J, Ebeling PR. Zoledronic acid prevents bone loss after allogeneic haemopoietic stem cell transplantation. Intern Med J. 2006;36:600–603
  16. Grigg AP, Shuttleworth P, Reynolds J, et al. Pamidronate reduces bone loss after allogeneic stem cell transplantation. J Clin Endocrinol Metab. 2006;91:3835–3843
  17. Chae YS, Kim JG, Moon JH, et al. Pilot study on the use of zoledronic acid to prevent bone loss in allo-SCT recipients. Bone Marrow Transplant. 2009;44:35–41
  18. Valimaki MJ, Kinnunen K, Volin L, et al. A prospective study of bone loss and turnover after allogeneic bone marrow transplantation: effect of calcium supplementation with or without calcitonin. Bone Marrow Transplant. 1999;23:355–361
  19. Massenkeil G, Fiene C, Rosen O, Michael R, Reisinger W, Arnold R. Loss of bone mass and vitamin D deficiency after hematopoietic stem cell transplantation: standard prophylactic measures fail to prevent osteoporosis. Leukemia. 2001;15:1701–1705
  20. Schimmer AD, Mah K, Bordeleau L, et al. Decreased bone mineral density is common after autologous blood or marrow transplantation. Bone Marrow Transplant. 2001;28:387–391
  21. Ebeling PR, Thomas DM, Erbas B, Hopper JL, Szer J, Grigg AP. Mechanisms of bone loss following allogeneic and autologous hemopoietic stem cell transplantation. J Bone Miner Res. 1999;14:342–350
  22. Gandhi MK, Lekamwasam S, Inman I, et al. Significant and persistent loss of bone mineral density in the femoral neck after haematopoietic stem cell transplantation: long-term follow-up of a prospective study. Br J Haematol. 2003;121:462–468
  23. Baim S, Wilson CR, Lewiecki EM, Luckey MM, Downs RW, Lentle BC. Precision assessment and radiation safety for dual-energy X-ray absorptiometry: position paper of the International Society for Clinical Densitometry. J Clin Densitom. 2005;8:371–378
  24. Warming L, Hassager C, Christiansen C. Changes in bone mineral density with age in men and women: a longitudinal study. Osteoporos Int. 2002;13:105–112
  25. Kanis JA. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group. Osteoporos Int. 1994;4:368–381
  26. Bushinsky DA, Monk RD. Electrolyte quintet: calcium. Lancet. 1998;352:306–311
  27. Manser R, Reid D, Abramson M. Corticosteroids for acute severe asthma in hospitalised patients. Cochrane Database Syst Rev. 2001;CD001740
  28. Sambrook PN, Cohen ML, Eisman JA, Pocock NA, Champion GD, Yeates MG. Effects of low dose corticosteroids on bone mass in rheumatoid arthritis: a longitudinal study. Ann Rheum Dis. 1989;48:535–538
  29. Sambrook PN, Eisman JA, Yeates MG, Pocock NA, Eberl S, Champion GD. Osteoporosis in rheumatoid arthritis: safety of low dose corticosteroids. Ann Rheum Dis. 1986;45:950–953
  30. Bataille R, Harousseau JL. Multiple myeloma. N Engl J Med. 1997;336:1657–1664
  31. Dhodapkar MV, Weinstein R, Tricot G, et al. Biologic and therapeutic determinants of bone mineral density in multiple myeloma. Leuk Lymphoma. 1998;32:121–127
  32. Callander NS, Roodman GD. Myeloma bone disease. Semin Hematol. 2001;38:276–285
  33. Sezer O, Heider U, Zavrski I, Kuhne CA, Hofbauer LC. RANK ligand and osteoprotegerin in myeloma bone disease. Blood. 2003;101:2094–2098
  34. Roodman GD. Mechanisms of bone lesions in multiple myeloma and lymphoma. Cancer. 1997;80:1557–1563
  35. Rossi JF, Bataille R, Chappard D, Alexandre C, Janbon C. B cell malignancies presenting with unusual bone involvement and mimicking multiple myeloma. Study of nine cases. Am J Med. 1987;83:10–16
  36. Rossi JF, Chappard D, Marcelli C, et al. Micro-osteoclast resorption as a characteristic feature of B-cell malignancies other than multiple myeloma. Br J Haematol. 1990;76:469–475
  37. Marcelli C, Chappard D, Rossi JF, et al. Histologic evidence of an abnormal bone remodeling in B-cell malignancies other than multiple myeloma. Cancer. 1988;62:1163–1170
  38. Gallacher S, Brankin E, Bessent R, Soukip M, Boyle I. Bone mineral density in adults with lymphoma. Bone. 1196;19:687.
  39. Weilbaecher KN. Mechanisms of osteoporosis after hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2000;6:165–174
  40. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006;81:353–373

 Financial disclosure: See Acknowledgments on page 1136.

PII: S1083-8791(10)00088-1

doi: 10.1016/j.bbmt.2010.02.017

Biology of Blood and Marrow Transplantation
Volume 16, Issue 8 , Pages 1130-1137 , August 2010

Article Tools

* Image Usage & Resolution