Biology of Blood and Marrow Transplantation
Volume 16, Issue 8 , Pages 1155-1161 , August 2010

Decreased Infections in Recipients of Unrelated Donor Hematopoietic Cell Transplantation from Donors with an Activating KIR Genotype

  • Marcie Tomblyn

      Affiliations

    • H. Lee Moffitt Cancer Center Department of Blood and Marrow Transplantation, Tampa, Florida
    • Corresponding Author InformationCorrespondence and reprint requests: Marcie Tomblyn, MD, Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612.
    • ,
  • Jo-Anne H. Young

      Affiliations

    • University of Minnesota Adult Blood and Marrow Transplant Program, Minneapolis/St. Paul, Minnesota
    • ,
  • Michael D. Haagenson

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Milwaukee, Wisconsin
    • ,
  • John P. Klein

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Milwaukee, Wisconsin
    • Division of Biostatistics Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Elizabeth A. Trachtenberg

      Affiliations

    • Center for Genetics, Children's Hospital Oakland Research Institute, Oakland, California
    • ,
  • Jan Storek

      Affiliations

    • University of Calgary, Calgary, Canada
    • ,
  • Stephen R. Spellman

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Milwaukee, Wisconsin
    • ,
  • Sarah Cooley

      Affiliations

    • University of Minnesota Adult Blood and Marrow Transplant Program, Minneapolis/St. Paul, Minnesota
    • ,
  • Jeffrey S. Miller

      Affiliations

    • University of Minnesota Adult Blood and Marrow Transplant Program, Minneapolis/St. Paul, Minnesota
    • ,
  • Daniel J. Weisdorf

      Affiliations

    • University of Minnesota Adult Blood and Marrow Transplant Program, Minneapolis/St. Paul, Minnesota
    • ,
  • on behalf of the CIBMTR Infection and Immune Reconstitution Working Committee

Received 11 December 2009 ,Accepted 23 February 2010.

  • Image Result

    Mean number of infections during the first 180 days following HCT. The mean number of infections is shown as the infection density defined as the number of infections per patient per days at risk and

    Mean number of infections during the first 180 days following HCT. The mean number of infections is shown as the infection density defined as the number of infections per patient per days at risk and normalized over the 180-day study period.

  • Image Result
    The cumulative incidence of bacterial infections in recipients of a KIR A/A genotype and a KIR B/x genotype unrelated donor graft.

    The cumulative incidence of bacterial infections in recipients of a KIR A/A genotype and a KIR B/x genotype unrelated donor graft.

  • Image Result
    The adjusted relative infection density for a KIR A/A (dotted bar) donor recipient compared to a KIR B/x (line) donor recipient during the first 180 days. A value above 1.0 indicates a higher mean rat

    The adjusted relative infection density for a KIR A/A (dotted bar) donor recipient compared to a KIR B/x (line) donor recipient during the first 180 days. A value above 1.0 indicates a higher mean ratio of infections in the KIR A/A cohort.

 Financial disclosure: See Acknowledgments on page 1160.

PII: S1083-8791(10)00097-2

doi: 10.1016/j.bbmt.2010.02.024

Biology of Blood and Marrow Transplantation
Volume 16, Issue 8 , Pages 1155-1161 , August 2010

Article Tools

* Image Usage & Resolution