Biology of Blood and Marrow Transplantation
Volume 16, Issue 8 , Pages 1155-1161 , August 2010

Decreased Infections in Recipients of Unrelated Donor Hematopoietic Cell Transplantation from Donors with an Activating KIR Genotype

  • Marcie Tomblyn

      Affiliations

    • H. Lee Moffitt Cancer Center Department of Blood and Marrow Transplantation, Tampa, Florida
    • Corresponding Author InformationCorrespondence and reprint requests: Marcie Tomblyn, MD, Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612.
    • ,
  • Jo-Anne H. Young

      Affiliations

    • University of Minnesota Adult Blood and Marrow Transplant Program, Minneapolis/St. Paul, Minnesota
    • ,
  • Michael D. Haagenson

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Milwaukee, Wisconsin
    • ,
  • John P. Klein

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Milwaukee, Wisconsin
    • Division of Biostatistics Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Elizabeth A. Trachtenberg

      Affiliations

    • Center for Genetics, Children's Hospital Oakland Research Institute, Oakland, California
    • ,
  • Jan Storek

      Affiliations

    • University of Calgary, Calgary, Canada
    • ,
  • Stephen R. Spellman

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Milwaukee, Wisconsin
    • ,
  • Sarah Cooley

      Affiliations

    • University of Minnesota Adult Blood and Marrow Transplant Program, Minneapolis/St. Paul, Minnesota
    • ,
  • Jeffrey S. Miller

      Affiliations

    • University of Minnesota Adult Blood and Marrow Transplant Program, Minneapolis/St. Paul, Minnesota
    • ,
  • Daniel J. Weisdorf

      Affiliations

    • University of Minnesota Adult Blood and Marrow Transplant Program, Minneapolis/St. Paul, Minnesota
    • ,
  • on behalf of the CIBMTR Infection and Immune Reconstitution Working Committee

Received 11 December 2009 ,Accepted 23 February 2010.

References 

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  9. Gaudieri S, DeSantis D, McKinnon E, et al. Killer immunoglobulin-like receptors and HLA act both independently and synergistically to modify HIV disease progression. Genes Immun. 2005;6:683–690
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  12. de Arias AE, Haworth SE, Belli LS, et al. Killer cell immunoglobulin-like receptor genotype and killer cell immunoglobulin-like receptor-human leukocyte antigen C ligand compatibility affect the severity of hepatitis C virus recurrence after liver transplantation. Liver Transpl. 2009;15:390–399
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  16. Chen C, Busson M, Rocha V, et al. Activating KIR genes are associated with CMV reactivation and survival after non-T-cell depleted HLA-identical sibling bone marrow transplantation for malignant disorders. Bone Marrow Transplant. 2006;38:437–444
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  24. Kim DH, Sohn SK, Lee NY, et al. Transplantation with higher dose of natural killer cells associated with better outcomes in terms of non-relapse mortality and infectious events after allogeneic peripheral blood stem cell transplantation from HLA-matched sibling donors. Eur J Haematol. 2005;75:299–308

 Financial disclosure: See Acknowledgments on page 1160.

PII: S1083-8791(10)00097-2

doi: 10.1016/j.bbmt.2010.02.024

Biology of Blood and Marrow Transplantation
Volume 16, Issue 8 , Pages 1155-1161 , August 2010

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