Biology of Blood and Marrow Transplantation
Volume 16, Issue 9 , Pages 1257-1264 , September 2010

Donor KIR Genes 2DL5A, 2DS1 and 3DS1 Are Associated with a Reduced Rate of Leukemia Relapse After HLA-Identical Sibling Stem Cell Transplantation for Acute Myeloid Leukemia but Not Other Hematologic Malignancies

  • Kate Stringaris

      Affiliations

    • Hematology Branch National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    • ,
  • Sharon Adams

      Affiliations

    • Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, Maryland, USA
    • ,
  • Marcela Uribe

      Affiliations

    • Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, Maryland, USA
    • ,
  • Rhoda Eniafe

      Affiliations

    • Hematology Branch National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    • ,
  • Colin O. Wu

      Affiliations

    • Office of Biostatistics Research, National Heart Lung and Blood Institute, Bethesda, Maryland, USA
    • ,
  • Bipin N. Savani

      Affiliations

    • Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    • ,
  • A. John Barrett

      Affiliations

    • Hematology Branch National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    • Corresponding Author InformationCorrespondence and reprint requests: A. John Barrett, MD, National Institutes of Health, Hematology Branch National Heart Lung and Blood Institute, Building 10-CRC/3-5330, Bethesda, MD 20892-1202.

Received 22 January 2010 ,Accepted 8 March 2010.

  • Image Result

    Factors affecting SCT outcome in multivariate analysis of 261 patients. (A) Lymphocyte count at day 30 posttransplant and TRM; (B) donor KIR genotype and relapse.

    Factors affecting SCT outcome in multivariate analysis of 261 patients. (A) Lymphocyte count at day 30 posttransplant and TRM; (B) donor KIR genotype and relapse.

  • Image Result

    Effect of donor KIR genes on relapse in AML patients (n = 68). (A) Stratified by donor KIR genes; (B) stratified by donor KIR and patient risk group.

    Effect of donor KIR genes on relapse in AML patients (n = 68). (A) Stratified by donor KIR genes; (B) stratified by donor KIR and patient risk group.

 Financial disclosure: See Acknowledgments on page 1263.

PII: S1083-8791(10)00109-6

doi: 10.1016/j.bbmt.2010.03.004

Biology of Blood and Marrow Transplantation
Volume 16, Issue 9 , Pages 1257-1264 , September 2010

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