Biology of Blood and Marrow Transplantation
Volume 16, Issue 9 , Pages 1231-1236 , September 2010

Corticosteroid Dose as a Risk Factor for Avascular Necrosis of the Bone after Hematopoietic Cell Transplantation

  • Sarah McAvoy

      Affiliations

    • Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota
    • ,
  • K. Scott Baker

      Affiliations

    • Survivorship Program, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Daniel Mulrooney

      Affiliations

    • Division of Pediatric Hematology-Oncology, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Anne Blaes

      Affiliations

    • Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Mukta Arora

      Affiliations

    • Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota
    • Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Linda J. Burns

      Affiliations

    • Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota
    • Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Navneet S. Majhail

      Affiliations

    • Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota
    • Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota
    • Corresponding Author InformationCorrespondence and reprint requests to: Navneet Majhail, MD, MS, Division of Hematology, Oncology and Transplantation, University of Minnesota, 420 Delaware Street SE, MMC 480, Minneapolis, MN 55455.

Received 4 January 2010 ,Accepted 7 March 2010.

References 

  1. Baker KS, Gurney JG, Ness KK, et al. Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation: results from the Bone Marrow Transplant Survivor Study. Blood. 2004;104:1898–1906
  2. Baker KS, Armenian S, Bhatia S. Long term consequences of hematopoietic stem-cell transplantation: current state of the science. Biol Blood Marrow Transplant. 2010;16(Suppl):S90–S96
  3. Baker KS, Ness KK, Steinberger J, et al. Diabetes, hypertension, and cardiovascular events in survivors of hematopoietic cell transplantation: a report from the bone marrow transplantation survivor study. Blood. 2007;109:1765–1772
  4. Fraser CJ, Bhatia S, Ness K, et al. Impact of chronic graft-versus-host disease on the health status of hematopoietic cell transplantation survivors: a report from the Bone Marrow Transplant Survivor Study. Blood. 2006;108:2867–2873
  5. Majhail NS, Ness KK, Burns LJ, et al. Late effects in survivors of Hodgkin and non-Hodgkin lymphoma treated with autologous hematopoietic cell transplantation: a report from the bone marrow transplant survivor study. Biol Blood Marrow Transplant. 2007;13:1153–1159
  6. Socie G, Stone JV, Wingard JR, et al. Long-term survival and late deaths after allogeneic bone marrow transplantation. Late Effects Working Committee of the International Bone Marrow Transplant Registry. N Engl J Med. 1999;341:14–21
  7. Enright H, Haake R, Weisdorf D. Avascular necrosis of bone: a common serious complication of allogeneic bone marrow transplantation. Am J Med. 1990;89:733–738
  8. Schulte CM, Beelen DW. Avascular osteonecrosis after allogeneic hematopoietic stem-cell transplantation: diagnosis and gender matter. Transplantation. 2004;78:1055–1063
  9. Wiesmann A, Pereira P, Bohm P, Faul C, Kanz L, Einsele H. Avascular necrosis of bone following allogeneic stem cell transplantation: MR screening and therapeutic options. Bone Marrow Transplant. 1998;22:565–569
  10. Schulte CM, Beelen DW. Low pretransplant bone-mineral density and rapid bone loss do not increase risk for avascular osteonecrosis after allogeneic hematopoietic stem cell transplantation. Transplantation. 2005;79:1748–1755
  11. Socie G, Cahn JY, Carmelo J, et al. Avascular necrosis of bone after allogeneic bone marrow transplantation: analysis of risk factors for 4388 patients by the Societe Francaise de Greffe de Moelle (SFGM). Br J Haematol. 1997;97:865–870
  12. Fink JC, Leisenring WM, Sullivan KM, Sherrard DJ, Weiss NS. Avascular necrosis following bone marrow transplantation: a case-control study. Bone. 1998;22:67–71
  13. Campbell S, Sun CL, Kurian S, et al. Predictors of avascular necrosis of bone in long-term survivors of hematopoietic cell transplantation. Cancer. 2009;115:4127–4135
  14. Fryer JP, Granger DK, Leventhal JR, Gillingham K, Najarian JS, Matas AJ. Steroid-related complications in the cyclosporine era. Clin Transplant. 1994;8:224–229
  15. Tauchmanova L, De Rosa G, Serio B, et al. Avascular necrosis in long-term survivors after allogeneic or autologous stem cell transplantation: a single center experience and a review. Cancer. 2003;97:2453–2461
  16. Socie G, Selimi F, Sedel L, et al. Avascular necrosis of bone after allogeneic bone marrow transplantation: clinical findings, incidence and risk factors. Br J Haematol. 1994;86:624–628
  17. Torii YMD, Hasegawa YMD, Kubo TMD, et al. Osteonecrosis of the femoral head after allogeneic bone marrow transplantation. Clin Orthop Relat Res. 2001;382:124–132
  18. Steinberg ME, Steinberg DR. Classification systems for osteonecrosis: an overview. Orthop Clin North Am. 2004;35:273–283vii-viii
  19. Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest. 1998;102:274–282
  20. Wang KZ, Mao LZ, Hu CG. [Experimental study on mechanism of steroid-induced avascular necrosis of femoral head]. Zhonghua Wai Ke Za Zhi. 1994;32:515–517
  21. Assouline-Dayan Y, Chang C, Greenspan A, Shoenfeld Y, Gershwin ME. Pathogenesis and natural history of osteonecrosis. Semin Arthritis Rheum. 2002;32:94–124
  22. Cruess R. Cortisone-induced avascular necrosis of the femoral head. J Bone Joint Surg Br. 1977;59-B:308–317

 Financial disclosure: See Acknowledgments on page 1236.

PII: S1083-8791(10)00113-8

doi: 10.1016/j.bbmt.2010.03.008

Biology of Blood and Marrow Transplantation
Volume 16, Issue 9 , Pages 1231-1236 , September 2010

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