Biology of Blood and Marrow Transplantation
Volume 16, Issue 9 , Pages 1272-1281 , September 2010

The Costs and Cost-Effectiveness of Allogeneic Peripheral Blood Stem Cell Transplantation versus Bone Marrow Transplantation in Pediatric Patients with Acute Leukemia

  • Yu-Feng Lin

      Affiliations

    • Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas
    • School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas
    • Corresponding Author InformationCorrespondence and reprint requests: Yu-Feng Lin, DrPH, Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030.
    • ,
  • David R. Lairson

      Affiliations

    • School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas
    • ,
  • Wenyaw Chan

      Affiliations

    • School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas
    • ,
  • Xianglin L. Du

      Affiliations

    • School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas
    • ,
  • Kathryn S. Leung

      Affiliations

    • Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas
    • ,
  • Alana A. Kennedy-Nasser

      Affiliations

    • Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas
    • ,
  • Caridad A. Martinez

      Affiliations

    • Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas
    • ,
  • Stephen M. Gottschalk

      Affiliations

    • Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas
    • ,
  • Catherine M. Bollard

      Affiliations

    • Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas
    • ,
  • Helen E. Heslop

      Affiliations

    • Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas
    • ,
  • Malcolm K. Brenner

      Affiliations

    • Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas
    • ,
  • Robert A. Krance

      Affiliations

    • Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas

Received 13 November 2009 ,Accepted 16 March 2010.

  • Image Result

    ICER of PBSCT (A) and BMT (B) in the standard-risk subgroup. The ICER was determined using 1000 Monte Carlo simulations to estimate the 95% confidence ellipse. Most points (77%) fell in quadrant II, i

    ICER of PBSCT (A) and BMT (B) in the standard-risk subgroup. The ICER was determined using 1000 Monte Carlo simulations to estimate the 95% confidence ellipse. Most points (77%) fell in quadrant II, indicating a higher probability that PBSCT was less effective and more costly than BMT.

  • Image Result
    ICER of PBSCT (A) and BMT (B) in the high-risk subgroup. The ICER was determined using 1000 Monte Carlo simulations to estimate the 95% confidence ellipse. There is a 37% probability that PBSCT would

    ICER of PBSCT (A) and BMT (B) in the high-risk subgroup. The ICER was determined using 1000 Monte Carlo simulations to estimate the 95% confidence ellipse. There is a 37% probability that PBSCT would be less costly but also less effective than BMT (quadrant III). PBSCT has an equivalent opportunity (24%) of being the dominant option (quadrant IV) or being the dominated choice (quadrant II) over BMT.

 Financial disclosure: See Acknowledgments, page 1279.

PII: S1083-8791(10)00122-9

doi: 10.1016/j.bbmt.2010.03.016

Biology of Blood and Marrow Transplantation
Volume 16, Issue 9 , Pages 1272-1281 , September 2010

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