Biology of Blood and Marrow Transplantation
Volume 16, Issue 9 , Pages 1293-1301 , September 2010

Platelet-lysate-Expanded Mesenchymal Stromal Cells as a Salvage Therapy for Severe Resistant Graft-versus-Host Disease in a Pediatric Population

  • Giovanna Lucchini

      Affiliations

    • Clinica Pediatrica, Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    • ,
  • Martino Introna

      Affiliations

    • USC Ematologia, Ospedali Riuniti di Bergamo, Bergamo, Italy
    • ,
  • Erica Dander

      Affiliations

    • Clinica Pediatrica, Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    • ,
  • Attilio Rovelli

      Affiliations

    • Clinica Pediatrica, Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    • ,
  • Adriana Balduzzi

      Affiliations

    • Clinica Pediatrica, Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    • ,
  • Sonia Bonanomi

      Affiliations

    • Clinica Pediatrica, Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    • ,
  • Agnese Salvadè

      Affiliations

    • Clinica Pediatrica, Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    • ,
  • Chiara Capelli

      Affiliations

    • USC Ematologia, Ospedali Riuniti di Bergamo, Bergamo, Italy
    • ,
  • Daniela Belotti

      Affiliations

    • Clinica Pediatrica, Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    • ,
  • Giuseppe Gaipa

      Affiliations

    • Clinica Pediatrica, Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    • ,
  • Paolo Perseghin

      Affiliations

    • Centro Trasfusionale-UOS Aferesi, Ospedale San Gerardo, Monza, Italy
    • ,
  • Paola Vinci

      Affiliations

    • Clinica Pediatrica, Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    • ,
  • Edoardo Lanino

      Affiliations

    • Dipartimento Ematologia-Oncologia Pediatrica, IRCCS Giannina Gaslini, Genova, Italy
    • ,
  • Patrizia Chiusolo

      Affiliations

    • Clinica Pediatrica, Istituto di Ematologia, Università Cattolica S. Cuore Roma, Italy
    • ,
  • Maria Grazia Orofino

      Affiliations

    • Clinica Pediatrica, Università di Cagliari, Cagliari, Italy
    • ,
  • Sarah Marktel

      Affiliations

    • Unità di Immunoematologia Pediatrica e Trapianto di Midollo Osseo, Istituto Scientifico Ospedale San Raffaele, Milano, Italy
    • ,
  • Jose Golay

      Affiliations

    • USC Ematologia, Ospedali Riuniti di Bergamo, Bergamo, Italy
    • ,
  • Alessandro Rambaldi

      Affiliations

    • USC Ematologia, Ospedali Riuniti di Bergamo, Bergamo, Italy
    • ,
  • Andrea Biondi

      Affiliations

    • Clinica Pediatrica, Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    • Corresponding Author InformationCorrespondence and reprint requests: Ettore Biagi, MD, or Prof. Andrea Biondi, Laboratory of Cell Therapy “Stefano Verri,” Laboratorio M.Tettamanti, Avancorpo settore C, Clinica Pediatrica, Ospedale S.Gerardo dei Tintori, Via Donizetti 106, 20052, Monza (Mi), Italy.
    • ,
  • Giovanna D'Amico

      Affiliations

    • Clinica Pediatrica, Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    • Ettore Biagi and Giovanna D'Amico are equal last authors.
    • ,
  • Ettore Biagi

      Affiliations

    • Clinica Pediatrica, Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    • Corresponding Author InformationCorrespondence and reprint requests: Ettore Biagi, MD, or Prof. Andrea Biondi, Laboratory of Cell Therapy “Stefano Verri,” Laboratorio M.Tettamanti, Avancorpo settore C, Clinica Pediatrica, Ospedale S.Gerardo dei Tintori, Via Donizetti 106, 20052, Monza (Mi), Italy.
    • Ettore Biagi and Giovanna D'Amico are equal last authors.

Received 17 February 2010 ,Accepted 20 March 2010.

  • Image Result

    Time-based monitoring of TNF-α and IFN-γ levels in patients treated with mesenchymal stromal cells (MSCs) (A, B): plasma levels of TNF-α and IFN-γ in patients with graft-versus-host-disease (GVHD) wer

    Time-based monitoring of TNF-α and IFN-γ levels in patients treated with mesenchymal stromal cells (MSCs) (A, B): plasma levels of TNF-α and IFN-γ in patients with graft-versus-host-disease (GVHD) were monitored at different time points after MSC infusion. Monitoring of 2 patients is shown. The GVHD of those patients was limited to the skin and GVHD score is expressed as overall grading.

 Financial disclosure: See Acknowledgments on page 1301.

PII: S1083-8791(10)00135-7

doi: 10.1016/j.bbmt.2010.03.017

Biology of Blood and Marrow Transplantation
Volume 16, Issue 9 , Pages 1293-1301 , September 2010

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