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Volume 17, Issue 5 , Pages 674-681 , May 2011

Acute Kidney Injury in Patients with Systemic Sclerosis Participating in Hematopoietic Cell Transplantation Trials in the United States

Chitra Hosing
- Department of Stem Cell Transplantation and Cellular Therapy, M.D. Anderson Cancer Center, Houston, Texas
- Correspondence and reprint requests: Chitra Hosing MD, Department of Stem Cell Transplantation and Cellular Therapy, M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 423, Houston, TX 77030.
Richard Nash
- Clinical Research Division, Department of Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington
Peter McSweeney
- Blood and Marrow Transplant Program, Rocky Mountain Cancer Center, Denver, Colorado
Shin Mineishi
- Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
James Seibold
- Division of Rheumatology, University of Michigan, Ann Arbor, Michigan
Linda M. Griffith
- Clinical Immunology Branch, Division of Allergy, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
Howard Shulman
- Department of Pathology, Fred Hutchinson Cancer Research Center, Seattle, Washington
Ellen Goldmuntz
- Clinical Immunology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
Maureen Mayes
- Division of Rheumatology, University of Texas, Houston, Texas
Chirag R. Parikh
- Department of Medicine, Yale University, New Haven, Connecticut
Leslie Crofford
- Division of Rheumatology, University of Kentucky, Lexington, Kentucky
Lynette Keyes-Elstein
- Senior Statistical Scientist, Rho, Inc, Chapel Hill, North Carolina
Daniel Furst
- Division of Rheumatology, University of California, Los Angeles, California
Virginia Steen
- Division of Rheumatology, Georgetown University, Washington, DC
Keith M. Sullivan
- Division of Cellular Therapy, Duke University Medical Center, Durham, North Carolina

Received 4 February 2010 ,Accepted 3 August 2010.

Periodic acid-Schiff–stained section of renal biopsy from patient 6. The glomerulus exhibits duplication of the basement membrane (arrowhead), segmental collapse of capillary loops, and mesangiolysis.

Periodic acid-Schiff–stained section of renal biopsy from patient 6. The glomerulus exhibits duplication of the basement membrane (arrowhead), segmental collapse of capillary loops, and mesangiolysis. An adjacent longitudinally oriented arteriole (arrow) has a small residual eccentric lumen nearly obliterated by myointimal matrix. (Original magnification, 40×.)
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Autopsy kidney from patient 8 with SRC. (A) Interlobular arteriole with severe luminal narrowing from “onion skin–like” myointimal hyperplasia. (Hematoxylin and eosin; original magnification, 40×.) (B

Autopsy kidney from patient 8 with SRC. (A) Interlobular arteriole with severe luminal narrowing from “onion skin–like” myointimal hyperplasia. (Hematoxylin and eosin; original magnification, 40×.) (B) The shrunken glomerulus exhibits a collapse of capillary loops with focal necrosis of endothelial cell (arrowhead). A contiguous afferent arteriole shows fibrinoid necrosis (arrow) within the thickened intimal layer. (Hematoxylin and eosin; original magnification, 40×.)
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