Biology of Blood and Marrow Transplantation
Volume 17, Issue 2 , Pages 270-273 , February 2011

Limbus Damage in Ocular Graft-versus-Host Disease

  • Rebeca Lorenzo Pérez

      Affiliations

    • Servicio de Oftalmología, Universidad de Salamanca, Salamanca, Spain
    • ,
  • Jose A. Pérez-Simón

      Affiliations

    • Servicio de Hematología, Universidad de Salamanca, Salamanca, Spain
    • Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y León
    • Corresponding Author InformationCorrespondence and reprint requests: Jose A. Pérez-Simón, MD, PhD, Servicio de Hematología, Hospital Clinico Universitario de Salamanca, Paseo de San Vicente s/n 37007, Salamanca, Spain.
    • ,
  • Teresa Caballero-Velazquez

      Affiliations

    • Servicio de Hematología, Universidad de Salamanca, Salamanca, Spain
    • ,
  • Teresa Flores

      Affiliations

    • Servicio de Anatomía Patológica del Hospital Universitario de Salamanca, Universidad de Salamanca, Salamanca, Spain
    • ,
  • Soraya Carrancio

      Affiliations

    • Servicio de Hematología, Universidad de Salamanca, Salamanca, Spain
    • ,
  • Carmen Herrero

      Affiliations

    • Servicio de Hematología, Universidad de Salamanca, Salamanca, Spain
    • ,
  • Belén Blanco

      Affiliations

    • Servicio de Hematología, Universidad de Salamanca, Salamanca, Spain
    • ,
  • Silvia Gutierrez-Cosio

      Affiliations

    • Servicio de Hematología, Universidad de Salamanca, Salamanca, Spain
    • ,
  • Cristina Cañete-Campos

      Affiliations

    • Servicio de Oftalmología, Universidad de Salamanca, Salamanca, Spain
    • ,
  • Fernando Cruz González

      Affiliations

    • Servicio de Oftalmología, Universidad de Salamanca, Salamanca, Spain
    • ,
  • Jesus F. San-Miguel

      Affiliations

    • Servicio de Hematología, Universidad de Salamanca, Salamanca, Spain
    • Centro de Investigación del Cáncer, Universidad de Salamanca, Salamanca, Spain
    • Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y León
    • Servicio de Hematologia, Hospital Universitario Virgen del Rocio/Instituto de Biomedicina de Sevilla (IBIS)
    • ,
  • Emiliano Hernández-Galilea

      Affiliations

    • Servicio de Oftalmología, Universidad de Salamanca, Salamanca, Spain
    • ,
  • Ignacio Sánchez-Abarca

      Affiliations

    • Servicio de Hematología, Universidad de Salamanca, Salamanca, Spain
    • Centro de Investigación del Cáncer, Universidad de Salamanca, Salamanca, Spain
    • Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y León

Received 4 April 2010 ,Accepted 17 August 2010.

References 

  1. Shulman HM, Sullivan KM, Weiden PL, et al. Chronic graft-versus-host syndrome in man: a long term clinicopathologic study of 20 Seattle patients. Am J Med. 1980;69:204–217
  2. Mencucci R, Ferrini CR, Bosi A, Volpe R, Guidi S, Salvi G. Ophthalmological aspects in allogenic bone marrow transplantation: Sjögren-like syndrome in graft-versus host disease. Eur J Ophthalmol. 1997;7:13–18
  3. Tichelli A, Duell T, Weiss M, et al. Late onset keratoconjunctivits sicca syndrome after bone marrow transplantation: incidence and risk factors. Bone Marrow Transplant. 1996;17:1105–1111
  4. Franklin RM, Kenyon KR, Tutschka PJ, et al. Ocular manifestations of graft-vs-host disease. Ophthalmology. 1983;90:4–13
  5. Ogawa Y, Okamoto S, Wakui M, et al. Dry eye after haematopoietic stem cell transplantation. Br J Ophthalmol. 1999;83:1125–1130
  6. Saito T, Shinagawa K, Takenaka K, et al. Ocular manifestation of acute graft-versus-host disease after allogenic peripheral blood stem cell transplantation. Int J Hematol. 2002;75:332–334
  7. Kim SK. Update on ocular graft versus host disease. Curr Opin Ophthalmol. 2006;17:344–348
  8. Anderson NG, Regillo C. Ocular manifestations of graft versus host disease. Curr Opin Ophthalmol. 2004;15:503–507
  9. Fijnheer R, Hettinga YM, Verdonck LF, Fijnheer R, Rijkers GT, Rothova A. Anterior uveitis: a manifestation of graft-versus-host disease. Ophthalmology. 2007;114:794–797
  10. Balaram M, Rashid S, Dana R. Chronic ocular surface disease after allogeneic bone marrow transplantation. Ocular Surface. 2005;3:203–211
  11. Ogawa Y, Masataka Kuwana MD. Dry eye as a major complication associated with chronic graft-versus-host disease after hematopoietic stem cell transplantation. Cornea. 2003;22:S19–S27
  12. Murphy PT, Sivakumaran M, Fahy G, et al. Successful use of topical retinoic acid in severe dry eye due to chronic graft-versus-host disease. Bone Marrow Transplant. 1996;18:641–642
  13. Rocha EM, Pelegrino FS, de Paiva CS, et al. GVHD dry eyes treated with autologous serum tears. Bone Marrow Transplant. 2000;25:1101–1103
  14. Ogawa Y, Okamoto S, Kuwana M, et al. Successful treatment of dry eye in two patients with chronic graft-versus-host disease with systemic administration of FK506 and corticosteroids. Cornea. 2001;20:430–434
  15. Hirst LW, Jabs DA, Tutschka PJ, et al. The eye in bone marrow transplantation. I. Clinical study. Arch Ophthalmol. 1983;101:580–584
  16. Jabs DA, Wingard J, Green WR, et al. The eye in bone marrow transplantation. III. Conjunctival graft versus host disease. Arch Ophthalmol. 1989;107:1343–1348
  17. Rojas B, Cuhna R, Zafirakis P, et al. Cell populations and adhesion molecules expression in conjunctiva before and alter bone marrow transplantation. Exp Eye Res. 2005;81:313–325
  18. Hassan AS, Clouthier SG, Ferrara JL, et al. Lacrimal gland involvement in graft-versus-host disease: a murine model. Invest Ophthalmol Vis Sci. 2005;46:2692–2697
  19. Shulman HM, Kleiner D, Lee SJ, et al. Histopathologic diagnosis of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. Pathology Working Group Report. Biol Blood Marrow Transplant. 2006;12:31–47
  20. Cooke KR, Kobzik L, Martin TR, et al. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood. 1996;8:3230–3239
  21. Ogawa Y, Kuwana M, Yamakazi K, et al. Periductal area as the primary site for T-cell activation in lacrimal gland chronic graft-versus-host disease. Invest Ophthalmol Vis Sci. 2003;44:1888–1896
  22. West RH, Szer J, Pedersen JS. Ocular surface and lacrimal disturbances in chronic graft-versus-host disease: the role of conjunctival biopsy. Aust N Z J Ophtalmol. 1991;19:187–191

 Financial disclosure: See Acknowledgments on page 273.

PII: S1083-8791(10)00347-2

doi: 10.1016/j.bbmt.2010.08.008

Biology of Blood and Marrow Transplantation
Volume 17, Issue 2 , Pages 270-273 , February 2011

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