Biology of Blood and Marrow Transplantation
Volume 17, Issue 5 , Pages 723-728 , May 2011

Unrelated Donor Bone Marrow Transplantation for Myelodysplastic Syndrome in Children

  • Paul Woodard

      Affiliations

    • Amgen, Thousand Oaks, California
    • ,
  • Paul A. Carpenter

      Affiliations

    • Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Stella M. Davies

      Affiliations

    • Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
    • ,
  • Thomas G. Gross

      Affiliations

    • Nationwide Children’s Hospital, Columbus, Ohio
    • ,
  • Wensheng He

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Milwaukee, Wisconsin
    • ,
  • Mei-Jie Zhang

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Milwaukee, Wisconsin
    • ,
  • Biljana N. Horn

      Affiliations

    • University of California San Francisco Medical Center, San Francisco, California
    • ,
  • David A. Margolis

      Affiliations

    • Children’s Hospital of Wisconsin, Milwaukee, Wisconsin
    • ,
  • John P. Perentesis

      Affiliations

    • Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
    • ,
  • Jean E. Sanders

      Affiliations

    • Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Kirk R. Schultz

      Affiliations

    • British Columbia’s Children’s Hospital, UBC, Vancouver, British Columbia, Canada
    • ,
  • Adriana Seber

      Affiliations

    • Instituto de Oncologia Pediatrica, Sao Paulo, Brazil
    • ,
  • William G. Woods

      Affiliations

    • Children’s Healthcare of Atlanta at Egleston, Aflac Cancer Center and Blood Disorders Services, Atlanta, Georgia
    • ,
  • Mary Eapen

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Milwaukee, Wisconsin
    • Corresponding Author InformationCorrespondence and reprint requests: Mary Eapen, MBBS, MS, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Suite C 5500, Milwaukee, WI 53226.

Received 16 July 2010 ,Accepted 18 August 2010.

References 

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  2. Locatelli F, Pession A, Bonetti F, et al. Busulfan, cyclophosphamide and melphalan as conditioning regimen for bone marrow transplantation in children with myelodysplastic syndromes. Leukemia. 1994;8:844–849
  3. Woods WG, Barnard DR, Alonzo TA, et al. Prospective study of 90 children requiring treatment for juvenile myelomonocytic leukemia or myelodysplastic syndrome: a report from the Children’s Cancer Group. J Clin Oncol. 2002;20:434–440
  4. Davies SM, Wagner JE, Defor T, et al. Unrelated donor bone marrow transplantation for children and adolescents with aplastic anaemia or myelodysplasia. Br J Haematol. 1997;96:749–756
  5. Yusuf U, Frangoul HA, Gooley TA, et al. Allogeneic bone marrow transplantation in children with myelodysplastic syndrome or juvenile myelomonocytic leukemia: the Seattle experience. Bone Marrow Transplant. 2004;33:805–814
  6. Deeg HJ, Storer B, Slattery JT, et al. Conditioning with targeted busulfan and cyclophosphamide for hemopoietic stem cell transplantation from related and unrelated donors in patients with myelodysplastic syndrome. Blood. 2002;100:1201–1207
  7. Hasle H, Niemeyer CM, Chessells JM, et al. A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases. Leukemia. 2003;17:277–282
  8. Przepiorka D, Weisdorf D, Martin P, et al. 1994 Consensus Conference on acute GVHD grading. Bone Marrow Transplant. 1995;15:825–828
  9. Atkinson K, Horowitz MM, Gale RP, et al. Risk factors for chronic graft-versus-host disease after HLA-identical sibling bone marrow transplantation. Blood. 1990;75:2459–2464
  10. Lin DY. Non-parametric inference for cumulative incidence functions in competing risks studies. Stat Med. 1997;16:901–910
  11. Klein J, Moeschberger M. Survival Analysis: Techniques of Censored and Truncated Data. New York: Springer-Verlag; 2003;
  12. Cox DR. Regression models and life tables. J R Stat Soc. 1972;34:187–202
  13. Lee SJ, Klein J, Haagenson M, et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood. 2007;110:4576–4583
  14. Kroger N, Zabelina T, Kruger W, et al. Comparison of total body irradiation vs busulfan in combination with cyclophosphamide as conditioning for unrelated stem cell transplantation in CML patients. Bone Marrow Transplant. 2001;27:349–354
  15. Ringden O, Remberger M, Ruutu T, et al. Increased risk of chronic graft-versus-host disease, obstructive bronchiolitis, and alopecia with busulfan versus total body irradiation: long-term results of a randomized trial in allogeneic marrow recipients with leukemia. Nordic Bone Marrow Transplantation Group. Blood. 1999;93:2196–2201
  16. Strahm B, Locatelli F, Bader P, et al. Reduced intensity conditioning in unrelated donor transplantation for refractory cytopenia in childhood. Bone Marrow Transplant. 2007;40:329–333
  17. Parikh SH, Mendizabal A, Martin PL, et al. Unrelated donor umbilical cord blood transplantation in pediatric myelodysplastic syndrome: a single-center experience. Biol Blood Marrow Transplant. 2009;15:948–955
  18. MorenoMadureira AB, Teira P, Locatelli F, et al. Risk factors analyses for outcomes after unrelated cord blood transplantation for children with myelodysplastic syndromes. An analysis on behalf of EWOG-MDS and Eurocord Groups. Blood. 2007;118:602a

 Financial disclosure: See Acknowledgments on page 727.

PII: S1083-8791(10)00365-4

doi: 10.1016/j.bbmt.2010.08.016

Biology of Blood and Marrow Transplantation
Volume 17, Issue 5 , Pages 723-728 , May 2011

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