Biology of Blood and Marrow Transplantation
Volume 17, Issue 5 , Pages 710-716 , May 2011

Platelet and Red Blood Cell Utilization and Transfusion Independence in Umbilical Cord Blood and Allogeneic Peripheral Blood Hematopoietic Cell Transplants

  • Melhem Solh

      Affiliations

    • Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Claudio Brunstein

      Affiliations

    • Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Shanna Morgan

      Affiliations

    • Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota
    • ,
  • Daniel Weisdorf

      Affiliations

    • Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota
    • Corresponding Author InformationCorrespondence and reprint requests: Daniel Weisdorf, MD, Blood and Marrow Transplant Program,Division of Hematology, Oncology and Transplantation,University of Minnesota, Mayo Mail Code 480; 420 Delaware Street SE, Minneapolis, MN 55455

Received 16 July 2010 ,Accepted 21 August 2010.

  • Image Result

    Time to RBC and platelet independence. In leukemia patients, shown is the cumulative incidence of the time to transfusion independence (untransfused Hb >8 g/dL; PLT >20,000/μL) in recipients of UCB or

    Time to RBC and platelet independence. In leukemia patients, shown is the cumulative incidence of the time to transfusion independence (untransfused Hb >8 g/dL; PLT >20,000/μL) in recipients of UCB or sibling donor PBSC grafts.

  • Image Result
    Marginal mean of platelet (A) and RBC (B) transfusion over time. Shown are the marginal means of cumulative PLT (A) and RBC (B) transfusions over the first 6 months post-HCT for patients with leukemia

    Marginal mean of platelet (A) and RBC (B) transfusion over time. Shown are the marginal means of cumulative PLT (A) and RBC (B) transfusions over the first 6 months post-HCT for patients with leukemia. UCB recipients have significantly greater mean PLT (P < .01) and RBC (P = .02) transfusion needs compared to PBSC.

 Financial disclosure: See Acknowledgments on page 715.

PII: S1083-8791(10)00366-6

doi: 10.1016/j.bbmt.2010.08.017

Biology of Blood and Marrow Transplantation
Volume 17, Issue 5 , Pages 710-716 , May 2011

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