Real-World Issues and Potential Solutions in Hematopoietic Cell Transplantation during the COVID-19 Pandemic: Perspectives from the Worldwide Network for Blood and Marrow Transplantation and Center for International Blood and Marrow Transplant Research Health Services and International Studies Committee
Correspondence and reprint requests: Mahmoud Aljurf, MD, Department of Adult Hematology and Stem Cell Transplantation, KFSHRC, Riyadh, SA, Zahrawi St, Al Maathe, Al Maazer, Riyadh 12713, KSA.
Department of Haematology. St George's Hospital and Medical School, London, United KingdomCell Therapy Facility, Blood Services Group, Health Sciences Authority, Singapore
Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Stockholm, SwedenDivision of Hematology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden
Cord Blood Bank, King Abdullah International Medical Research Center, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia
Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New YorkWeill Cornell Medical College, New York, New York
Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio
Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Washington and Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
Department of Adult Hematology and Stem Cell Transplant, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi ArabiaDepartment of Internal Medicine, Mayo Clinic, Rochester, Minnesota
The current COVID-19 pandemic, caused by SARS-CoV-2, has impacted many facets of hematopoietic cell transplantation (HCT) in both developed and developing countries. Realizing the challenges as a result of this pandemic affecting the daily practice of the HCT centers and the recognition of the variability in practice worldwide, the Worldwide Network for Blood and Marrow Transplantation (WBMT) and the Center for International Blood and Marrow Transplant Research's (CIBMTR) Health Services and International Studies Committee have jointly produced an expert opinion statement as a general guide to deal with certain aspects of HCT, including diagnostics for SARS-CoV-2 in HCT recipient, pre- and post-HCT management, donor issues, medical tourism, and facilities management. During these crucial times, which may last for months or years, the HCT community must reorganize to proceed with transplantation activity in those patients who urgently require it, albeit with extreme caution. This shared knowledge may be of value to the HCT community in the absence of high-quality evidence-based medicine.
In recent history, several epidemics have affected the care of hematopoietic cell transplantation (HCT) recipients/donors, including severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV-1), influenza A virus subtype H1N1, Zika virus, and Ebola virus. The issues arising from these epidemics were relatively geographically limited compared with the current COVID-19 pandemic, caused by SARS-CoV-2. By July 19, 2020, more that 13 million cases of COVID-19 had been reported worldwide [
]. Numerous aspects of the virus remain unknown, including the immune response and natural course of the disease, the exact incubation period, and the rate of spread among asymptomatic people, among other factors. These uncertainties make it particularly challenging to study the pattern of possible spread and create efficient management and prevention strategies. It is also difficult to predict the disease severity of COVID-19 in HCT recipients. Thus far, limited data have been published on disease severity, clinical course, and duration of infectivity of COVID-19 in HCT recipients [
Balduzzi A, Brivio E, Rovelli A, et al. Lessons after the early management of the COVID-19 outbreak in a pediatric transplant and hemato-oncology center embedded within a COVID-19 dedicated hospital in Lombardia, Italy [e-pub ahead of print]. Estote parati. Bone Marrow Transplant. doi:10.1038/s41409-020-0895-4, Accessed 19 July 2020.
]. Importantly, HCT remains the standard of care and the sole potential curative therapy for many hematologic malignancies, genetic diseases, hemoglobinopathies, autoimmune diseases, and immunodeficiencies [
Indications for autologous and allogeneic hematopoietic cell transplantation: guidelines from the American Society for Blood and Marrow Transplantation.
Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey.
]. The transplantation community is facing many challenges concerning the day-to-day practice of HCT, with disruptions in the entire process of referrals for evaluation, scheduling, admission, chemotherapy/radiation administration, donor procurement, and discharge planning, among other aspects (Figure 1).
Figure 1General principles for management of HCT patients during the SARS-CoV-2 pandemic.
SARS-CoV-2 is a highly communicable virus that incites a variable immune response, resulting in uncertainties about protective as well as deleterious immune responses to the virus. Although the majority of infected individuals clear the virus without major complications, in a minority of the patients, the infection leads to a life-threatening clinical situation involving any organ (especially the lungs), diffuse intravascular thrombosis, and ultimately acute respiratory distress syndrome (ARDS) and multiorgan failure, which has a complex pathology and mechanism [
Whether the incidence of the severe syndrome of COVID-19 infection is diminished or enhanced in patients post-HCT relative to the general population or other cancer populations, and what risk factors are predictive of lower respiratory infection and infection severity, are unclear at present. In addition, many donor issues have arisen as a consequence of global lockdown, travel restrictions, and quarantine procedures in various countries. Finally, many drugs currently used in the HCT arena, such as Bruton's tyrosine kinase inhibitors (eg, ibrutinib), ruxolitinib, tocilizumab, azithromycin, and mesenchymal stromal cells (all used to treat acute or chronic graft-versus-host-disease [GVHD]), are being studied in clinical trials to evaluate their efficacy (or lack thereof) for treating COVID-19 and/or its complications. Therefore, many practice issues regarding the use of these agents in HCT recipients are currently under debate.
The Worldwide Network for Blood and Marrow Transplantation (WBMT) is a nonprofit organization for education, scientific inquiry, and philanthropy serving all aspects of HCT under the laws of Switzerland and as a nongovernmental organization (NGO) in an official relationship with the World Health Organization (WHO) since 2007. The WBMT serves philanthropic purposes concerning aspects of global HCT and represents 22 international societies working in the field and more than 1600 transplantation centers worldwide. The Center for International Blood and Marrow Transplant Research (CIBMTR) is a working group of >380 international transplantation centers (and a founding member of the WBMT) that collects detailed information on autologous and allogeneic HCT recipients as well as on recipients of cellular therapies, such as chimeric antigen receptor (CAR) T cell therapy. The CIBMTR's Health Services and International Studies Committee deals with aspects related to HCT. The WBMT and CIBMTR experts and leadership acknowledge the challenges of the COVID-19 crisis that may differ in developing vs developed countries.
While acknowledging all the aforementioned challenges and taking into account current recommendations and guidelines issued by the American Society for Transplantation and Cellular Therapy and the European Society for Blood and Marrow Transplantation (EBMT) (both of which are WBMT members), here we aim to provide a consensus opinion from the WBMT, the CIBMTR's Health Services and International Studies Committee, and other HCT experts from multiple continents regarding the current worldwide threat to HCT recipients from the COVID-19 pandemic [
Ljungman P, Mikulska M, de la Camara R, et al. The challenge of COVID-19 and hematopoietic cell transplantation; EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapy [e-pub ahead of print]. Bone Marrow Transplant. doi: 10.1038/s41409-020-0919-0, Accessed 19 July 2020.
]. For Recommendations regarding the management of patients being treated with CAR T cell therapy are presented in a recent publication on this topic [
Creating hospital-wide multidisciplinary COVID-19 teams (including specialists in infectious diseases, critical care medicine, pulmonary medicine, etc) is essential to facilitate the management of patients and make adjustments based on new information as it becomes available. Enabling telephone or video communication for multidisciplinary team meetings is important for the coordinated care of patients. To facilitate reporting, some registries, including the CIBMTR and EBMT, are actively collecting information on HCT and other cellular therapy patients infected with COVID-19. HCT programs require adequate HCT staff resuming transplantations during the COVID-19 pandemic.
SUPPORTIVE CARE
Continuing availability of blood products is a prerequisite for planning HCT, given that blood supply has been a major issue during the pandemic. The possibility of reducing the threshold for blood product transfusion should be discussed at the beginning of HCT. In addition, blood loss prevention strategies (eg, minimizing blood draws or treatment with tranexamic acid if clinically permissible) should be maximized [
]. The use of pediatric tubes and reassessment of scheduled laboratory work may be useful as well.
Holistic management of patients remains as essential as ever, maybe more important than ever. Patients undergoing HCT should have regular visits with social support services, given the uncertainties around returning to work and associated healthcare costs, particularly those in a jurisdiction without universal healthcare, to minimize financial and social toxicity. It is appropriate to vigilantly monitor for the psychological effects of the current COVID-19 pandemic on HCT survivors and the staff taking care of them. At the same time, the risk of infection from these visits must be considered, including such factors as the time after HCT. Additional measures to ensure construction of well-rounded management plans include providing appropriate physiotherapy and nutritional guidance.
Transplantation pharmacists should continuously monitor the potential drug toxicities and interactions of the medications given post-HCT via telehealth. In addition, the drug inventory should be evaluated at routine intervals for the essential drugs used for HCT patients. The use of any over-the-counter drugs or self-treatment with complementary and alternative medicine without discussion with the primary transplantation physician and the clinical pharmacist is not recommended. We refer the readers to the American Society for Transplantation and Cellular Therapy’s pharmacy practice management guideline for COVID-19 patients [
American Society for Transplantation and Cellular Therapy Pharmacy Special Interest Group position statement on pharmacy practice management and clinical management for COVID-19 in hematopoietic cell transplantation and cellular therapy patients in the United States.
COVID-19: CLINICAL SPECTRUM AND DIAGNOSTIC TESTING
Individuals infected with SARS-CoV-2 can present with a variety of symptoms, including fever, rhinorrhea, cough, chest pain, shortness of breath, diarrhea, and skin rash.
Two kinds of tests are available for COVID-19: a viral test using PCR to detect the virus and an antibody-based test to detect the occurrence of previous infection (which can take 1 to 3 weeks after infection to become positive). Notably, PCR-based testing does not distinguish between live and dead SARS-CoV-2. For diagnosing COVID-19 infection in HCT recipients, testing with real-time RT-PCR ideally should be done on nasopharyngeal swabs; however, sputum samples and nasal swabs also can be used [
]. Each center needs to understand the sensitivity, specificity, and predictive values of the specific test being used, which may be affected by the regional prevalence of the infection. Pitfalls in SARS-CoV-2 PCR diagnostics have been reported recently [
]. At present, there is no known role for antibody-based (serologic) testing for SARS-CoV-2 for diagnostic purposes. Exposure (especially to contacts with COVID-19 patients) and symptom history, physical examination, and chest imaging are helpful in evaluating HCT recipients.
In the event that the diagnosis is not clear, bronchoscopy with bronchoalveolar lavage may be pursued in selected cases, albeit with extreme caution because this procedure also puts the pulmonologist at risk of acquiring the SARS-CoV-2 infection. Specific symptoms/findings ascribed to SARS-CoV-2 infection including fever, chills, cough, shortness of breath or difficulty breathing, fatigue, muscle/body aches, headache, new loss of taste or smell, sore throat, congestion or runny nose, nausea or vomiting, and diarrhea. The degree of symptoms may range from asymptomatic (eg, no fever) to mild to severe [
]. Laboratory tests, such as C-reactive protein, D-dimer, and lactate dehydrogenase levels, may help assess the severity of infection and optimally should be performed in every patient with confirmed COVID-19 [
]. Suspected patients with classic COVID-19 symptoms in an appropriate medical setting may be cohorted or isolated as soon as possible in special wards or units (temporary or permanent depending on the institutional policies and/or resources). Only when the RT-PCR test comes back negative should these patients be considered standard-risk HCT recipients and managed accordingly. In the absence of appropriate diagnostic tools (ie, RT-PCR), physicians may need to rely on history, physical exam, and chest imaging, in which case a chest computed tomography scan may be helpful, as it is more sensitive than a chest radiograph.
HCT-RELATED TREATMENTS AND COVID-19 THERAPIES
Currently approved therapies for COVID-19 complications include remdesivir in the United States (under emergency use authorization) and Japan and tocilizumab in China. Ongoing clinical trials are examining various treatment protocols. At present, there are no regulatory agency–approved therapies or vaccines for the treatment or prevention of COVID-19. Hydroxychloroquine, alone or in combination with azithromycin, has been widely used based on anecdotal and limited observational evidence.
On June 15, 2020, the US Food and Drug Administration (FDA) revoked chloroquine and hydroxychloroquine's emergency use authorization in response to the publication of new scientific data showing that these drugs are unlikely to be effective in treating COVID-19 [
Principi N, Esposito S.Chloroquine or hydroxychloroquine for prophylaxis of COVID-19 [e-pub ahead of print]. Lancet Infect Dis. doi: 10.1016/S1473-3099(20)30296-6, Accessed 19 July 2020.
]. In light of ongoing serious cardiac adverse events and other potential serious side effects, the potential benefits of chloroquine and hydroxychloroquine do not outweigh the risks of their use. The US Centers for Disease Control and Prevention has removed both drugs from its guidelines.
Table 1 reviews several of these agents, including their current uses in HCT recipients and in treating GVHD. It is important to consider the possible increased risk of complications in HCT recipients with COVID-19 owing to the status of immune reconstitution (delayed in allogeneic HCT recipients for up to a year), concurrent medications including immunosuppressive drugs, the general state of the patient (ie, performance status and psychosocial condition), existing comorbidities (especially cardiovascular and pulmonary), presence or absence of GVHD, disease status (ie, COVID-19 severity), mucositis (because mucosal barrier injury predisposes to infection), and malnutrition (which itself can suppress the immunologic response to infection) [
Fung M, Babik JM. COVID-19 in immunocompromised hosts: what we know so far. Clin Infect Dis. doi: 10.1093/cid/ciaa863. Accessed 19 July 2020. [e-pub ahead of print].
]. In addition, superimposed bacterial infection, fungal infection, and reactivation of other common viral infections, such as cytomegalovirus or Epstein-Barr virus infection, may occur, and patients should be closely monitored and treated as indicated. There are no data to support the discontinuation of immunosuppressive drugs in HCT recipients infected with COVID-19. At present, little data are available on the effectiveness of various drugs/immunomodulators for treating COVID-19; however, numerous randomized clinical trials are currently underway using a variety of agents for COVID-19 management. Therefore, we recommend that unapproved drug use in HCT recipients should be considered in a clinical trial or approved for exceptional use after hospital Ethics Committee approval.
Table 1Agents Considered for the Treatment of COVID-19 Relevant to HCT, and Common Drugs Used in HCT Relevant to COVID-19 Infection
Drug Name
COVID-19 Studies
Use in HCT
Special Considerations
Agents with the greatest promise
Remdesivir
Benefit in animal models against the MERS virus and SARS virus; therefore, may have potential activity against COVID-19 [
If supply is an issue, then reserve it for COVID-19 patient clinical trials and use alternate agents for acute GVHD.
CAR T cell approved therapy may be affected due to the restricted availability of this drug; thus, consider limiting CAR T cell therapy to those with an urgent need.
Convalescent plasma recovered from COVID-19 patients
Failure of clinical improvement in 2 case series [
Can cause QTc prolongation, torsades de pointes, ventricular tachycardia, and sudden cardiac death, especially when used together with chloroquine.
A significant number of patients with GVHD will also be on “azoles” for antifungal prophylaxis, so the risk of QTc prolongation could be further enhanced if used concurrently with full-dose azithromycin, chloroquine, or both.
Chloroquine and hydroxychloroquine
Best evidence thus far has failed to demonstrate benefit in hard clinical outcomes, but some trial results have been encouraging, with a suggestion of reduced viral load or reduced PCR positivity of COVID-19
Mehra MR, Desai SS, Ruschitzka F, Patel AN. RETRACTED: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis. Lancet. 5-22-2020. doi: https://doi.org/10.1016/S0140-6736(20)31180-6.
Severe GI symptoms, QTc prolongation, and multiple drug interactions due to CYP3A inhibition, especially with salmeterol-fluticasone, which, as the FAM protocol, is used frequently used to treat BOS.
Favipiravir
Preliminary results of a Japanese clinical trial showed that in COVID-19, compared with arbidol, favipiravir did not significantly improve the clinical recovery rate at day 7
Treatment for HCT-associated microangiopathy (TTP).
Given its association with a serious increase in the risk of infection (meningococcus), use only in clinical trials.
Siltuximab
An improvement in the clinical condition was observed in 33% (7 of 21) of patients, 43% (9 of 21) of patients stabilized, as evidenced by no clinically relevant change in their condition, and 24% (5 of 21) experienced a worsening of their condition
Approved by the EMA and FDA for treatment of adults with HHV6-/HIV- multicentric Castleman's disease
Use only in the context of clinical trials.
Ruxolitinib
Possible role in hemophagocytic lymphohistiocytosis due to COVID-19 (trials started)
Approved for the treatment of steroid-refractory acute GVHD.
Risk of infection and thrombocytopenia with full-dose ruxolitinib. Thrombocytopenia and an ITP-like syndrome have been described in COVID-19 patients; thus, cautious use in clinical trials only is recommended.
Ibrutinib
Reported as perhaps beneficial for COVID-19 in a retrospective study
RECOVERY Collaborative Group; Horby P, Lim WS, et al. Dexamethasone in hospitalized patients with Covid-19: preliminary report [e-pub ahead of print]. N Engl J Med. doi:10.1056/NEJMoa2021436. Accessed 19 July 2020.
Early, low-dose and short-term application of corticosteroid treatment in patients with severe COVID-19 pneumonia: single-center experience from Wuhan, China.
Approved treatment for acute GVHD in Canada, New Zealand, and Japan
Can be used in the context of clinical trials both autologous and allogeneic HCT recipients.
Multiple trials going on in ARDS due to COVID-19
Interactions with other drugs
Voriconazole and posaconazole
No known role in COVID-19
Commonly used in GVHD.
Azithromycin interaction with the CYP3A4 inducers.
CAR T cells (cryopreserved vs. fresh products)
No role in COVID-19
Approved for post-transplantation relapse of ALL and NHL.
Post-CAR T cell infusion, any drug treatment should strictly be in the context of clinical trials.
CAR T cell therapy may be affected owing to the restricted availability of tocilizumab; therefore, consider CAR T cell therapy only for those with an urgent need.
General guidance from the CAR T cell consortium should be considered
An exploratory randomized controlled study on the efficacy and safety of lopinavir/ritonavir or arbidol treating adult patients hospitalized with mild/moderate COVID-19 (ELACOI).
PRETRANSPLANTATION PLANNING AND TRANSPLANTATION MANAGEMENT
Successful coordination of an HCT program with the overall strategy of the hospital or health system for coping with the current pandemic is needed. It is important to ensure that the staff is protected so that the center does not experience loss of expert personnel to exposure (necessitating quarantine) or infection. Strict adherence to infection control measures is imperative to minimize the transmission of the virus in HCT inpatient and outpatient units.
All patients, including those without symptoms, should be thoroughly evaluated for clinical symptoms that might suggest incipient COVID-19, and both symptomatic and asymptomatic patients should be tested for SARS-CoV-2 with RT-PCR 1 or 2 days before entering the transplantation ward for conditioning. In patients at high risk of acquiring SARS-CoV-2, such as patients exposed to persons with active upper respiratory tract infection symptoms, then a second RT-PCR analysis is advisable even if the first RT-PCR was negative, owing to the possibility of false-negative results. In addition, a computed tomography scan of the chest can be very helpful in these cases, given its greater sensitivity than chest radiography [
Xu B, Xing Y, Peng J, et al. Chest CT for detecting COVID-19: a systematic review and meta-analysis of diagnostic accuracy. Eur Radiol. doi: 10.1007/s00330-020-06934-2. Accessed 19 July 2020. [e-pub ahead of print].
]. Centers should allocate adequate space for symptomatic patients awaiting the results of SARS-CoV-2 testing; ideally, this should be in a negative-pressure room preferably separate from the transplantation unit. Patients scheduled for transplantation should attempt to reduce the risk of exposure by home isolation for at least 14 days before starting conditioning. If the transplantation is postponed owing to concerns about intensive care unit capacity or infection prevalence, it is imperative to complete the proper risk assessments and clearly communicate the reasons for the delay to the patient. Furthermore, it is necessary to document the multidisciplinary meeting discussions in the medical record.
From the WBMT perspective, the decision to proceed to transplantation should be individualized, weighing the risks for serious complications from COVID-19 infection against the risks of disease progression if HCT is delayed.
Urgent Transplantations
Delaying urgent transplantations, such as for acute leukemias, high-risk myelodysplastic syndrome, and certain refractory bone marrow failure syndromes, and autologous HCTs (if being performed for curative intent) for high-risk myelomas, Hodgkin lymphoma, large cell lymphomas, or germ cell tumors in patients at substantial risk of loss of disease control is not recommended.
Nonurgent Transplantations
In general, nonurgent transplants should be deferred as clinically permissible, especially for patients with stable, slowly progressive, nonmalignant disorders, such as hemoglobinopathies, selected immunodeficiencies, and selected genetic conditions.
DONOR ISSUES
In general, using peripheral blood stem cells (PBSCs) with cryopreservation and testing the quality of thawed product before the start of conditioning are strongly encouraged. The use of post-transplantation cyclophosphamide has increased significantly worldwide for both haploidentical and HLA-matched HCTs, and a recent study showed no detrimental effect of cryopreserved products on survival when using post-transplantation cyclophosphamide for GVHD prophylaxis in patients undergoing HCT for hematologic malignancies [
]. Therefore, we consider this a reasonable strategy for HCT for hematologic malignancies; however, for bone marrow failure (especially for severe aplastic anemia), fresh bone marrow products remain the standard of care, as supported by a recent study [
American Society for Transplantation and Cellular Therapy Pharmacy Special Interest Group position statement on pharmacy practice management and clinical management for COVID-19 in hematopoietic cell transplantation and cellular therapy patients in the United States.
]. According to the FDA, no confirmed or suspected cases of transfusion-transmitted COVID-19 have been reported to date. Current American Association of Blood Banks guidelines do not recommend universal screening for SARS-CoV-2 in blood products, and current FDA guidelines recommend considering the donor's infection and exposure history in the 28 days before donation [
]. The World Marrow Donor Association has also produced recommendations and we endorse those guidelines (Table 2). Within 28 days before donation, donors should avoid any contact with individuals with a syndrome suggestive of COVID-19, crowded places, and large gatherings.
Table 2Recommendations for evaluation of HCT donors
Donor Status
Recommendation
History of COVID-19 infection
Collection should be deferred for at least 28 days after recovery.If the patient's need for transplant is urgent, the donor is completely well and there are no suitable alternative donors, earlier collection may be considered if local public health requirements permit
Contact with COVID-19 – donors who report contact with a confirmed case
Collection should be deferred for 4 weeks after a donor's last contact with a person with confirmed COVID-19 infection.If the patient's need for transplant is urgent, the donor is completely well and there are no suitable alternative donors, earlier collection may be considered if local public health requirements permit, subject to careful risk assessment.
Donors who have travelled internationally or reside in a high risk country
Ideally, a backup donor should be available, but this might not be possible in all cases. PBSCs should be used unless there is a strong indication for using bone marrow. The rationale for using PBSCs is less need for blood transfusions (due to earlier engraftment), no need for using inpatient rooms and personal protective equipment for bone marrow harvest, and faster neutrophil engraftment, which may result in earlier discharge of recipients. Coordination with the local and international authorities (especially with the border customs officials in certain countries) may be needed to ensure trouble-free transport of cell therapy products. Donor safety issues must be a top priority during this pandemic, and the World Marrow Donor Association and the local donor stem cell registry recommendations should be followed. In some countries, the use of umbilical cord blood units as a backup strategy may be preferred, depending on the existing resources and current practices.
The role of postconvalescent plasma for prevention and therapy remains undefined, and this should be used only in clinical trials. Many trials are currently running or in evaluation. The standardization of antibody concentration remains an important issue.
MANAGING COVID-19 INFECTION IN THE PERITRANSPLANTATION PERIOD
Given the lack of data on the management of patients infected with COVID-19 who are undergoing HCT, the treatment paradigm should follow the institutional policies. In general, if SARS-CoV-2 is suspected or confirmed before the initiation of a conditioning regimen, then HCT should be delayed until the patient completely recovers from the infection (at least 14 days). Two consecutive negative RT-PCR analyses (at least 1 day apart) are advised for confirmed cases. For scenarios during the conditioning regimen, the following principles may help.
If conditioning has proceeded to a point at which the risk of myelosuppression or myeloablation is low, then subsequent doses may be withheld. If conditioning duration/intensity has passed that point, then conditioning should be completed and the HCT product infused. If sufficient myeloablative conditioning has been delivered to a recipient and SARS-CoV-2 is confirmed, the transplantation process should continue owing to anticipated bone marrow aplasia. The COVID-19 infection should be managed symptomatically or on a clinical trial with a cautious evaluation of drug-drug interactions.
If infection with COVID-19 is diagnosed on the day of transplantation (day 0), then HCT should proceed as intended, with no delays in the PBSC or bone marrow infusion. Convalescent plasma infusions, if indicated for COVID-19 infection on a clinical trial, should be avoided on the day of transplantation to minimize the risk of allergic reactions.
If the COVID-19 infection is diagnosed after the stem cell infusion, then it should be treated symptomatically and/or on a clinical trial, taking the possibility of manageable drug interferences into account (Table 1).
In all other scenarios, the patient should be evaluated by a multidisciplinary team for an individualized decision.
HOSPITALIZATION AND TRANSPLANTATION
Special infection control measures, including strict use of proper personal protective equipment, should be followed as recommended by international, national, and local guidelines. A team/unit dedicated to the care of COVID-19 patients should be separated and isolated from staff caring for HCT recipients. Ideally, there should be a specific site/unit for cohorting these patients. Some hospitals in developing countries may have little capacity for private rooms; nonetheless, given their immunocompromised state, HCT recipients should not be cohorted in shared rooms.
Regarding the selection of the appropriate industrial climate control system for HCT recipients, we recommend the following:
HCT recipients with suspected COVID-19 should not stay in a positive-pressure room. They should be tested in a neutral-pressure (or negative-pressure) room (a private room if available). If RT-PCR is not available and/or suspicion is high, the patient should be kept in a private room (neutral or negative pressure) if possible, or cohorted. It may be advisable to perform these tests immediately before admission and wait for results if possible.
HCT recipients with confirmed COVID-19 infection should not stay in a positive-pressure room and must be transferred to a negative-pressure (or neutral-pressure) room immediately.
HCT recipients with a negative test for SARS-CoV-2 and no symptoms should continue being managed in a high-efficiency particulate air (HEPA)-filtered positive-pressure room in accordance with the institutional policy for immunocompromised patients.
Staff should be screened for symptoms before entering the HCT unit, and surgical face masks and eye protection should be worn at all times during ward rounds, as recommended by the EBMT [
Ljungman P, Mikulska M, de la Camara R, et al. The challenge of COVID-19 and hematopoietic cell transplantation; EBMT recommendations for management of hematopoietic cell transplant recipients, their donors, and patients undergoing CAR T-cell therapy [e-pub ahead of print]. Bone Marrow Transplant. doi: 10.1038/s41409-020-0919-0, Accessed 19 July 2020.
]. Social distancing rules should be strictly enforced. The number of individuals should be minimized during ward rounds and adequate distance from patients maintained to the degree possible. For the protection of the patient and the medical team, visitors should not be allowed during the hospital stay. An exception may be made in extraordinary circumstances (eg, patient dying from COVID-19) if this does not represent a conflict with the hospital's strategy or policies. Video communication may help in such circumstances.
Prophylactic G-CSF therapy for early neutrophil engraftment may be considered for HCT recipients unless contraindicated. There is no published evidence indicating that this practice can improve outcomes; however, there could be an advantage of early hospital discharge to reduce the risk of infection. Theoretically, the inflammatory cascade in ARDS [
] (mediated in part by IL-6) may be enhanced by cytokines; however, at present there are no data to support G-CSF administration. Cytokines may accelerate the risk of ARDS in confirmed cases of COVID-19 [
Nawar T, Morjaria S, Kaltsas A, et al. Granulocyte-colony stimulating factor in COVID-19: is it stimulating more than just the bone marrow? Am J Hematol. doi: 10.1002/ajh.25870. Re-accessed 19 July 2020.
]. The transfusion thresholds should be minimized in the light of an actual or anticipated shortage of blood products. As a general guideline, a hemoglobin threshold of <70 g/L should be considered as an indication for blood transfusion in both autologous and allogeneic HCT recipients [
Liberal versus restrictive red blood cell transfusion thresholds in hematopoietic cell transplantation: a randomized, open label, phase III, noninferiority trial.
]. For platelet transfusion, a threshold of <10 × 109/μL is reasonable in most cases.
POST-TRANSPLANTATION MANAGEMENT
HCT recipients may be at increased risk for both secondary infections and organ damage from COVID-19. The usual recommendations for infection prevention, including maintaining strict hand hygiene, wearing surgical or procedural masks at all times, and practicing social/physical distancing, should be strongly encouraged.
Outpatient visits should be postponed or conducted using telephone and/or televideo conferences where indicated. During the early post-HCT period, especially for allogeneic HCT recipients, a face-to-face visit may be necessary to detect early signs of acute GVHD of the skin and mucosa. Ambulatory transplantations should be encouraged to minimize exposure to hospital visits, if the necessary infrastructure is available.
Prolonged viral shedding, a common occurrence with other respiratory viruses, is likely in HCT recipients. Separate areas in outpatient settings for potential infectious and noninfectious individuals should be available, with checkpoints at the entrance. Patients with confirmed COVID-19 infection should be tested regularly (depending on the institutional policies and/or governmental regulations) until the RT-PCR results turn negative. Until then, these patients should be considered potentially infectious. Other important issues to address include social distancing and mask wearing in the waiting area, direct rooming (ie, no waiting), barring of visitors from the outpatient area, and avoidance of common areas (including cafeteria).
A real-world practice question is when and how to manage an HCT recipient who contracts COVID-19 post-transplantation. This should be an individualized decision. As general guidance, autologous HCT recipients beyond 6 months post-transplantation and allogeneic HCT recipients beyond 1-year post-transplantation without immunosuppression and GVHD may be treated according to general COVID-19 management guidelines. This has practical implications for vaccinations and COVID-19 treatment strategies. If possible, these patients should be cared for in the transplantation center and entered into a clinical trial if available. Of note, the role of convalescent plasma for treatment of COVID-19 has not been proven in the allogeneic HCT setting.
TRAVEL FOR HCT AND MEDICAL TOURISM
Patients requiring HCT in a country that has facilities for HCT should ideally stay in their home country, provided that their clinical condition allows for a delay in the procedure. This may be different for international travel within driving distance. For example, patients with severe aplastic anemia will have particular difficulty if no transplantation center in their home country performs allogeneic HCT for bone marrow failure syndromes, and timely HCT may be required in pediatric patients diagnosed with certain inherited conditions (eg, Hurler’s syndrome).
Patients who underwent HCT in a foreign country should avoid travel back to their respective countries in the immediate post-HCT period, especially if they are currently residing in a country/state/province/city that has an extremely high prevalence of SARS-CoV-2. HCT recipients who will require frequent visits in the initial months following HCT should remain at the original transplantation center until their clinical condition stabilizes (eg, 3 to 4 months after allogeneic HCT).
CONCLUSIONS
The COVID-19 pandemic has impacted all aspects of HCT. We believe that our shared knowledge will be of value to the HCT community in the current absence of high-quality evidence-based medicine. This emergency situation may persist for months or even years until herd immunity is achieved, owing to the availability of an effective vaccine or as a result of natural infection. During these crucial times, the HCT community must reorganize to proceed with transplantation in those who urgently need it and concurrently deal with the factors that accompany a pandemic, such as prevention of nosocomial transmission, protection of HCT staff, and treatment of COVID-19 in HCT recipients. The extreme changeability of the global geopolitical climate due to COVID-19 requires that HCT programs rethink their practices. We hope that this article provides general guidance to clinicians and institutional leadership to deal with the real-world scenarios.
ACKNOWLEDGMENTS
Financial disclosure:
Conflict of interest statement: M.K. has received honoraria from Gilead and Alexion. M.K.D. has served as a consultant for Pharmacyclics and Daiichi Sankyo. M.H. has received research support/funding from Takeda Pharmaceutical, Spectrum Pharmaceuticals, and Astellas Pharma; served as a consultant for Janssen R&D and Incyte; and served on the speaker's bureau for Sanofi Genzyme and AstraZeneca. D.W. reports research support from Incyte and consulting fees from FATE. S.H. reports honoraria and travel funding from Pfizer, Novartis, Gilead, Merck, Sanofi, Mallinckrodt, and Janssen. M.-A.P. has received honoraria from Abbvie, Bellicum, Celgene, Bristol-Myers Squibb, Incyte, Kite/Gilead, Merck, Novartis, Nektar Therapeutics, Omeros, and Takeda; has served on data safety and monitoring boards for Cidara Therapeutics, Servier, and Medigene and scientific advisory boards for MolMed and NexImmune; has received research support for clinical trials from Incyte, Kite/Gilead; and Miltenyi Biotec; and serves in a volunteer capacity as a member of the Board of Directors of Be The Match (National Marrow Donor Program), as well as on the CIBMTR Cellular Immunotherapy Data Resource Executive Committee. C.C. reports honoraria/travel funding from Astellas Pharma, Gilead, Merck, and Pfizer. A.W. has received research support from Ansun, WB Tech, Amazon and Allovir, and is a consultant for Kyorin.
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